About
Poly Cystic Ovarian Syndrome is an incurable disease affecting approximately 10% of the female population.Links
Who's Behind Golden Shoes?
Cole Imperi is the Director and Founder of Golden Shoes. She was diagnosed with PCOS in April of 2008. Kara Evans is the President of Golden Shoes.Following
From: HERE
Thomson R, Buckley J, Moran L, Noakes M, Clifton P, Norman R, Brinkworth G.
Australian Technology Network Centre for Metabolic Fitness & Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia.
Objective
To assess maximal aerobic capacity () and muscle strength in overweight and obese women with polycystic ovary syndrome (PCOS) and determine their relationship with metabolic and hormonal factors. Design Cross-sectional study. Setting Clinical Research Unit. Population Overweight and obese women with PCOS (n = 10) and age-and weight-matched healthy controls (n = 16). Methods was measured during an incremental treadmill test and maximal isometric (ImS) and isokinetic knee extensor strength (IkS) (120 degrees /second) were assessed by isokinetic dynamometry. Main outcome measures , ImS, IkS, waist circumference, blood lipids, glucose, insulin, insulin resistance (homeostatic model assessment [HOMA2]), C-reactive protein (CRP), hormonal profile.
Results
PCOS women had higher levels of testosterone and free testosterone (P </= 0.05), but there were no significant differences in any cardiovascular disease (CVD) risk markers between the groups. was similar in women with PCOS and healthy controls (PCOS 26.0 +/- 4.1 ml/kg/minute, controls 25.7 +/- 3.8 ml/kg/minute; P = 0.90), as was ImS (PCOS 1.50 +/- 0.54 Nm/kg, controls 1.50 +/- 0.47 Nm/kg; P = 0.96) and IkS (PCOS 1.04 +/- 0.32 Nm/kg, controls 1.16 +/- 0.23 Nm/kg; P = 0.32). was inversely related to waist circumference, insulin, HOMA2 and CRP. Waist circumference was inversely associated with ImS and IkS. No significant associations between exercise parameters and hormonal variables were identified.
Conclusions
Compared to age- and weight-matched healthy overweight and obese women with similar insulin resistance and CVD risk profiles, women with PCOS had similar aerobic capacity and muscle strength. This suggests PCOS, at least in the absence of an adverse metabolic profile is unlikely to limit physical function. Larger studies examining the effects of PCOS on exercise tolerance in a diverse range of PCOS phenotypes is required.
PMID: 19438498 [PubMed - as supplied by publisher
From: HERE
Park HT, Cho GJ, Ahn KH, Shin JH, Kim YT, Hur JY, Kim SH, Lee KW, Kim T.
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Objective: To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS). Design/patients/measurements: We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin, RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR), and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles.
Results: Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR, and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH.
Conclusion: An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.
PMID: 19438903 [PubMed - as supplied by publisher]
From: http://www.ncbi.nlm.nih.gov/pubmed/19443458?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Berker B, Kaya C, Aytac R, Satiroglu H.
Department of Obstetrics and Gynecology, Ankara University, Ankara, Turkey.
BACKGROUND A poor quality of oocytes and embryos and a low fertilization rate have been found in polycystic ovary syndrome (PCOS) patients. An inverse association between follicular fluid homocysteine (Hcy) levels and oocyte and embryo quality has also been demonstrated. We examined the relationship between follicular fluid Hcy concentrations and oocyte and embryo quality in PCOS patients undergoing assisted reproduction.
METHODS Fifty-two PCOS patients were included in the study, and underwent GnRH agonist/recombinant FSH treatment. The Hcy, folate, vitamin B(12), malonyldialdehyde (MDA) and estradiol (E(2)) levels were measured in follicular fluid from single oocytes at time of retrieval. One follicle per ovary was sampled and 94 were analysed. Plasma hormones were also measured. Oocytes and embryos were graded (1-3) using standard approaches.
RESULTS The concentrations of Hcy, E(2), vitamin B(12), folate and MDA in plasma were higher than in follicular fluid (all P < 0.001). Significant differences were observed in follicular Hcy levels between Grade 3 and Grade 2 oocytes (P < 0.001). Hcy levels were lower in Grade 1-2 embryos than that in Grade 3 embryos; follicular fluid vitamin B(12) levels were lower in patients showing high concentrations of follicular fluid Hcy (P < 0.01). The follicular fluid Hcy levels were negatively correlated with follicular fluid vitamin B(12) (r = -0.44), folate (r = -0.68) and fertilization rate (r = -0.85), and positively correlated with follicular fluid MDA (r = 0.51).
CONCLUSIONS Concentrations of Hcy in follicular fluid on the dOPU may be a useful marker for fertilization rate, and oocyte and embryo quality in PCOS patients undergoing assisted reproduction.
PMID: 19443458 [PubMed - as supplied by publisher]
Reprinted from a Juice Plus Newsletter Spring/Summer 2006
Summary: Women who are trying to conceive or currently pregnant appear to have pregnancies with fewer complications when on Juice Plus. Of particular interest is the part about preeclampsia, which is a common complication in women with PCOS.
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….There’s such a rapid acceleration of tissue growth and, as a result, a rapid acceleration of free radical damage [oxidative stress]. I’ve always recommended ‘standard issue’ prenatal vitamins. But we started to see healthier pregnancies more often when I started to add Juice Plus+® to the regimen.”
Over time, Dr. Odom and his nursing staff noticed that with the Juice Plus+® moms, they were seeing fewer Caesarean deliveries (“C-sections”), fewer premature deliveries, and a lower incidence of preeclampsia – a condition of late pregnancy that is characterized by high blood pressure and that can be potentially life-threatening to both mother and baby. They also noticed that the newborns of these moms tended to have higher birth weights, fewer admissions to neonatal intensive care units, and
a lower incidence of respiratory distress syndrome.
“It made sense to me that better nutrition would lead to healthier moms,” Dr. Odom recalls. “So, I decided to get a little more formal about my Juice Plus+® observations.
“Looking back to January 2000, I categorized expectant mothers into two groups: one composed of women who took Juice Plus+® (two Orchard Blend and two Garden Blend capsules) every day in addition to prenatal vitamins, the other comprised of women who took prenatals only.” Dr. Odom “matched” subjects for age, ethnicity, prior pregnancies, and insurance status – “everything I could think of to make sure that the two groups were as close to identical as possible” – and ended up with 178 mothers in his Juice Plus+® group and 178 in his non-Juice Plus+® comparison group.
Dr. Odom compared pregnancy outcomes by reviewing the medical records of all 356 patients after delivery. “The results even surprised me,” he confides. He found that women who had added Juice Plus+® to their regimen had significantly fewer
Caesarean deliveries (47% versus 66%), no premature deliveries before 37 weeks (compared to 35 women or 20% of the comparison group), and no diagnosed incidents of preeclampsia (versus 38 cases or 21% of the comparison group).
The Juice Plus+® babies fared better as well. They weighed about a half-pound more at birth on average (7 pounds, 11 ounces versus 7 pounds, 3 ounces). None of the Juice Plus+® babies had to be admitted to neonatal intensive care (compared to 17 or almost 10% of the comparison group babies).
Similarly, none of the Juice Plus+® babies studied were diagnosed with respiratory distress syndrome (versus 13 or 8% of the non-Juice Plus+® babies).
Dr. Odom offers a simple explanation: “Healthier moms have healthier babies.”
Dr. Odom presented these findings to his medical colleagues at the annual meeting of the Central Association of Obstetricians and Gynecologists in October 2003. The findings are also being published as a “retrospective descriptive analytic comparison” in the March 2006 issue of JANA, the Journal of the American Nutraceutical Association.
More importantly, Dr. Odom’s findings have led to the initiation of a methodologically rigorous (prospective, double-blind, placebo-controlled, and randomized) clinical trial of the impact of Juice Plus+® on pregnancy health currently underway at the University of Mississippi Medical Center in Jackson. “I am pleased to see that what I observed in our practice is now being taken to the next level of scientific investigation by my academic colleagues. I know that better nutrition leads to better outcomes.”
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Remember, Golden Shoes is not a doctor, or a medical professional of any kind. We post this information as is and make no guarantees. All information is for use at your own risk. Always be sure to talk with your doctor and remember, it’s your body, and your choice.
Many people ask to see a ‘before’ and ‘after’ shot of PCOS. Well, here’s one. These photos were taken only 10 months apart, but as you can see, they document a drastic change. Cole (director and founder of Golden Shoes) was nice enough to let us share this with the world. “I’d like to mention this isn’t really an ‘after’ since PCOS is incurable,” says Cole, “I hope this helps other women see that once you get your PCOS managed, drastic (and positive) change will begin to take place.”
My Hair is Growing Back!
@JennyWrites on Twitter asked me a question today about my hair growing back.
It’s taken about 9 months since I started on Metformin (Glucophage XR is what I really take) to start seeing mine come back. One morning I woke up and noticed all these little hairs lining my hairline—it was very obvious in the mirror. I thought I just broke a bunch of my hairs by wearing my ponytail holder too tight. (I know, I know. You don’t wear your ponytail that close to your forehead, but when you have PCOS you generally assume the worst.)
Then, more and more little hairs started showing up. Little hairs started to stick up and stick out. And I realized….it’s coming back!
My hair has also gotten thicker all over. It’s not as thick as it was pre-puberty, but it’s MUCH thicker than last year.
See photo for proof. ;) See those little hairs curliqueing in?